Blar i forfatter "Pedersen, Mona I."

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    • Overexpression of miR-20a-5p in Tumor Epithelium Is an Independent Negative Prognostic Indicator in Prostate Cancer — A Multi-Institutional Study 

      Stoen, Maria J.; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona I.; Ingebriktsen, Lise M.; Donnem, Tom; Lombardi, Ana P. G.; Kilvaer, Thomas K.; Busund, Lill-Tove R.; Richardsen, Elin (Master thesis; Mastergradsoppgave; Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-26)
      <p><i>Background:</i> MicroRNAs (miRs) have critical regulatory roles in cell functions, and are involved in prostate cancer tumorigenesis. miR-20a-5p is a member of the oncogenic miR-17-92 cluster. Overexpressed miR-20a-5p has been shown to increase both cell proliferation and cell migration in cancers. The aim of our cohort study was to evaluate the prognostic role of miR-20a-5p in prostate cancer. ...

    • Overexpression of mir-20a-5p in tumor epithelium is an independent negative prognostic indicator in prostate cancer—a multi-institutional study 

      Stoen, Maria J.; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona I.; Ingebriktsen, Lise M.; Dønnem, Tom; Lombardi, Ana P. G.; Kilvaer, Thomas K.; Rasmussen Busund, Lill-Tove; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-14)
      <i>Objective</i>: assessing the prognostic role of miR-20a-5p, in terms of clinical outcome, in a large multi-institutional cohort study.<br><br> <i>Methods</i>: Tissue microarrays from 535 patients’ prostatectomy specimens were constructed. In situ hybridization was performed to assess the expression level of miR-20a-5p in different tissue subregions: tumor stroma (TS) and tumor epithelium (TE). ...